Reversion of pH-Induced Physiological Drug Resistance: A Novel Function of Copolymeric Nanoparticles
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چکیده
منابع مشابه
Reversion of pH-Induced Physiological Drug Resistance: A Novel Function of Copolymeric Nanoparticles
AIMS The extracellular pH of cancer cells is lower than the intracellular pH. Weakly basic anticancer drugs will be protonated extracellularly and display a decreased intracellular concentration. In this study, we show that copolymeric nanoparticles (NPs) are able to overcome this "pH-induced physiological drug resistance" (PIPDR) by delivering drugs to the cancer cells via endocytosis rather t...
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ژورنال
عنوان ژورنال: PLoS ONE
سال: 2011
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0024172